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Interventions N-acetylcysteine (dosing range, 1200-3000 mg/d) or placebo was administered for 12 weeks. Data analysis was performed from July 16 to September 9, 2015.

Objective To determine whether N-acetylcysteine, an amino acid that appears to restore extracellular glutamate concentration in the nucleus accumbens, will be more effective than placebo in reducing compulsive picking behavior.ĭesign, Setting, and Participants A randomized, double-blind trial was conducted at ambulatory care centers at the University of Minnesota (September 12, 2011, to June 15, 2012) and the University of Chicago (December 17, 2012, to June 26, 2015) and included 66 adults with SPD. To date, there has been no clearly effective pharmacologic or psychological treatment for SPD. Importance Excoriation (skin-picking) disorder (SPD) is a disabling, underrecognized condition in which individuals repeatedly pick at their skin, leading to noticeable tissue damage.

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